Molecular switch helps guard against inflammatory disease

Source: Molecular switch helps guard against inflammatory disease – Medical News Today

Our immune system is a fine-tuned concert of surveillance and response that protects our health. While we know inbuilt mechanisms prevent overreactions that can lead to inflammatory diseases such as rheumatoid arthritis, we are not clear about how they work. Now, scientists have discovered a molecular switch inside cells that appears to suppress immune overreaction and avert inflammation.
simple depiction of cells
The researchers found that a molecule that normally resides inside the nucleus accumulates in the cell fluid outside of the nucleus during immune responses and acts to prevent over-inflammation.

The researchers, from Umeå University and the University of Gothenburg, both in Sweden, report the discovery in the journal Immunity. They hope it will help the development of new treatments for inflammatory diseases.

Nelson O. Gekara, an assistant professor in molecular biology and leader of the Umeå contingent, says the discovery of the switch – called MYSM1 – is “a major milestone in our understanding of how our immune system works, and how its response could be controlled in order to prevent inflammatory diseases such as sepsis.”

The innate immune system is triggered when pattern-recognition receptors detect certain molecular configurations on microbes and other undesirable material like dead cells. These receptors then activate inflammatory responses to eliminate the pathogen.

Most infections or inflammations involve numerous pattern-recognition receptor pathways working at the same time and in sequence. Such a complex cascade of events needs to be carefully synchronized to avoid a disproportionate self-destructive immune response, says Prof. Gekara, but exactly how this is accomplished is not clear.

His group has been investigating this area for several years – looking for genes that might be involved in fine-tuning the immune response.

MYSM1 ‘guards against self-destructive immune response’

In the new study, where the Umeå group teamed up with a group at the University of Gothenburg, the authors describe finding MYSM1 – a molecule in the nucleus of resting cells.

They note how during infection or inflammation, MYSM1 builds up in the fluid surrounding the nucleus – the cell cytoplasm – and blocks signals that activate pattern-recognition receptor pathways, thus terminating inflammation.

The team observed how mice deficient in MYSM1 developed hyper-inflammation and became susceptible to septic shock.

On further investigation, they found two structures in MYSM1 suppress the immune reaction: “the SWIRM domain that interacted with TRAF3 and TRAF6 and the metalloproteinase domain that removed K63 polyubiquitins.”

The researchers liken the molecule to a switch that turns off several inflammation pathways. Too little MYSM1 results in unrestrained activation of the innate immune system, leading to inflammatory diseases, as they note in their conclusion:

“This study identifies MYSM1 as a key negative regulator of the innate immune system that guards against an overzealous self-destructive immune response.”

Prof. Gekara’s team is now looking for compounds that, through regulating MYSM1 activity, might lead to new treatments for inflammatory diseases.

The discovery highlights the fine balance the immune system strikes between eliminating threats and promoting disease. Medical News Today recently learned of another example of this where researchers found that a tolerant immune system may be a risk factor for some cancers, and showed how a way to measure immune tolerance can predict the risk of developing them.

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